Mechanotransductive Engineering of Neural Stem Cell Behavior
نویسندگان
چکیده
منابع مشابه
Substrate modulus directs neural stem cell behavior.
Although biochemical signals that modulate stem cell self-renewal and differentiation were extensively studied, only recently were the mechanical properties of a stem cell's microenvironment shown to regulate its behavior. It would be desirable to have independent control over biochemical and mechanical cues, to analyze their relative and combined effects on stem-cell function. We developed a s...
متن کاملP70: Produce Neural Stem Cell from Neurosphere of Rat Adipose Derived Stem Cell
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملEngineering biomaterials for synthetic neural stem cell microenvironments.
Neural stem cells (NSCs) have been isolated from various speciesssuch as mice, rats, and humanssand from numerous regions in the developing and adult nervous systemsincluding the subventricular zone (SVZ), the subgranular zone of the hippocampus, the cortical neuroepithelium, and the spinal cord. In vivo, the NSC is encompassed by a microenvironment or niche that presents it with a repertoire o...
متن کاملBiomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.
Highly-regulated signals surrounding stem cells, such as growth factors at specific concentrations and matrix mechanical stiffness, have been implicated in modulating stem cell proliferation and maturation. However, tight control of proliferation and lineage commitment signals is rarely achieved during growth outside the body, since the spectrum of biochemical and mechanical signals that govern...
متن کاملStem Cell Organoid Engineering
Organoid systems leverage the self-organizing properties of stem cells to create diverse multicellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.2181